Title: "Human Consensus Sodium-Iodide Symporter Repressor (NIS-
Repressor) Binding Site”
Inventors: Kenneth Ain and Dr. Wei Li (Hematology Oncology)
Technical Description: The invention relates to a consensus nucleotide
sequence found within two kilobases ofthe 5 prime end of 56 different genes
in the human genome and use of this sequence to screen for compounds and
other molecules that inhibit transcription or that interfere with transcription
repressors or repressor complexes.
Summary: Human sodium-iodine symporter (hNIS) is a trans-membrane
protein enabling thyrocyte, both benign and malignant, to concentrate iodine,
pennitting radioiodine to be a unique systemic cytotoxic therapy for
metastatic tumors. Unfortunately, when hNIS expression is lost in
dedifferentiated thyroid carcinomas, there are no effective systemic agents for
treating metastatic tumors. Because of its role in inhibiting the transport of
iodine into thyroid cancer cells, there is a need to detennine the hNIS
repressor binding sites, structure and activities so that anti-thyroid cancer
therapies can be maximized.
4. U.S. Patent Application Serial Number: 13/ 005,213
Filed: January 12, 2011
Title: "High Activity Mutants of Butyrylcholinesterase for Cocaine
Hydrolysis”
Inventors: Chang-Gao Zhan, Fang Zheng and Wennchao Yang (Phannacy)
Teclmical Description: The disclosure relates to butyrylcholinesterase
(BChE) variant polypeptides, and in particular BChE mutants with amino acid
substitutions.
Summary: Cocaine abuse is a mq or medical and public health problem that
continues to defy treatment. This disclosure is an approach to cocaine abuse
treatment that interferes with the delivery of cocaine to its receptors and
accelerates its metabolism in the body.
5. U.S. Patent Application Serial Number: 13/018,641
Filed: February 1, 2011
Title: "High Activity Mutants of Butyrylcholinesterase for Cocaine
Hydrolysis”
Inventors: Chang-Gao Zhan, Fang Zheng and Wennchao Yang (Phannacy)
Teclmical Description: The disclosure relates to butyrylcholinesterase
(BChE) variant polypeptides, and in particular BChE mutants with amino acid
substitutions.
Summary: Cocaine abuse is a mq or medical and public health problem that
continues to defy treatment. This disclosure is an approach to cocaine abuse
treatment that interferes with the delivery of cocaine to its receptors and
accelerate its metabolism in the body.
6. U.S. Patent Application Serial Number: 13/015,837
Filed: January 28, 2011