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Image 8 of Kentucky Alumni, vol. 74, no. 4, Winter 2003

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, , ‘ I ··v·i.‘ · » r » »¤ · ;» r i -tt - I , . » . - - ..tr g; yi- I t i `I ” V ~l i A -ii j i ; i “ . é ~, V , .< ». ( p lt i UK Gene Research l Mlg GIVE clues analysis, a high-tech method that can examine the be- q to Organ ‘REgEnBI•ati¤n’ havior of thousands of genes at the same time. In ‘ B RBI h Dmcksgn preparation for the study, some 45,000 salamander I V li gene fragments have been sequenced, with most of j the work performed at a robotic workstation in Voss’ P Collaborative research at the University of Kentucky laboratory. r and the University of California, Irvine, involving the ge- "Once the key genes involved in regeneration ` netic structure of salamanders might offer clues about have been identified, they can be sequenced in full · regeneration of living tissue. and compared with those in other animals, including E "Clearly, there is a lot of interest in the regeneration humausf ggjd VcSS_ “Wc atc vcyy excited about thc , ol` tissues, and tissue repair in Org21DiSmS is within f€3Ch,ii next few years, I have a great group of people in my said Stephen Randal Voss, an assistant professor in the lab and our department has some of the finest equip- * Department of Biology in the UK College of Arts and ment in the country for pursuing questions of this na- i Sciences. “l~Iowever, we are a long way from understand- tuyc_" » ing how to coax the human body into regenerating com- Voss’ research is funded by three different sources. plex body parts after injury or disease," he said. Voss is In 2001, he was awarded a $500,000, five-year Na- hoping that powerful genetic approaches and an atypical tional Science Foundation CAREER Research grant research organism will reveal clues about regeneration and a five—year, $1.4 million grant from the National p in humans Institutes of I—Iealth.This past December, he was Voss and David Gardiner, a research professor of bi- awarded a $300,000, three—year grant from the Ken- ology at UC—lrvine, are engaged in an extensive research tucky Spina] Coyci Hcud Injury Rcgcurch Trust to t project l`undcd by the National Science Foundation to look at spinal cord regeneration. ` characterize genes that are expressed during limb regen- t eration in a Mexican salamander called the Axolotl _ (named for an Aztec god).Salamanders can regenerate SQc|a| WQrk t¤ complex body parts like a tail or a leg, but a couple hun- * dred years of study has revealed relatively little about Program iiiiiiiiiiiiziiig piiiccsi . Thanks to a three-year, $600,000 grant from the U.S. ln some ways, we know more about their early de- Department Of Health and Human Services, the UK """" , , Vciiifiifiiiiii iiiiiii we do iiiioiii Oui College of Social Work will participate in a program i · ' iiWii‘ Siiid VOSS Tiiiiy make huge to help incarcerated fathers bond with their children. I W iiiiiisiiiciiiii eggs and you can Wiiicii The Fathers and Children Together (FACT) , i ·‘ iiiciii m¤*¤r<—= iiiiiiii Q miigiiiiyiiig giiissii programs philosophy is to reduce the potential for (/° , Biii iikc ii iiii iii iiaiiy ifiiifiicii Oigaii child abuse and neglect by promoting fathers’ in- I ~» ¤m—A><¤*¤**S tell OM *¤V<>tWh€¤S<=l· volvement in the isa of their carats. by msg li ¢ iiiicii iiiiiicii iii Oiigiiiiisms Wiiii iiisi positive father/child experiences and opportunities W generation times that could be easily for lcamm inside Yiwu FACT - - · tl d ‘ . z z ·d in the laborator g · ii ' is iom y Spcmsorc I l · fb limp ig iii‘ _ . y' by Prevent Child Abuse Kentucky (PCAK) and ` id iiiiwiii/Ci` Wiiii iiiii iccciii iidviiiii Oi Blackburn Correctional Complex (BCC) Mary Se- ~ · tools that can be used to rapidly character- Crm, associate professor in the College Ofsocial '“ M9 iiii iii iii? gciics iii fiiiy_iiigiiiiiSm‘ miiiiy mi` Work, will serve as principal investigator examining ditional research models like the Axolotl are the Costs and the benefits Of the Lcxmgmmbascd being re-examined, with the hope that novel YO mm I insights will be gained about human health ii g ` y and disease. "When salamander regenera- \ I tion occurs," Voss said. `“certain genes within the salamander are turned on and others are i turned oI`l`." ._ As has been discovered recently for other vertebrates like fish, chicken, mice and humans, there are probably ' around 35.000 genes in a salamander. From this pool, F0,. more mformmion about Voss and ( iardncr plan to identify important regenera- i ,} research taking place at UK, tion genes from the Axolotl using DNA microchip visit WWW·*8S·“kY·°d“ and · .·?·:%‘1Z*¢?:Z?`;?-t www.mc.uky.edu Compiled from news reports about research at UK. 6 KliNTl’(`KY/\l.llMNl