Coagulation of Tobacco Smoke Aerosol



     This project is very impressive.   It addresses a critical area in tobacco

smoke technology: What are the physical changes in smoke between the time it

leaves the cigarette and the time it impinges on human tissue or the tissue

laboratory test systems?   An understanding of these changes is critical for

the design of experimental studies and for the interpretation of experimental

results.    The  approach  is  good   and  brings   a  variety  of  measurement

methodologies together in the studies of particle coagulation.        The work

should deserve high priority in the program of THRI.



                           V. Product Modification



     A number of investigators have made very significant contributions to all

projects relating to smoke generation and inhalation by experimental animals.

The methodology and protocol they have developed should markedly reduce the

variabililty in smoke exposure and, in so doing, will increase the statistical

reliability of experimental data.



     A vast majority of the funded projects are concerned with studies of

cardiovascular, pulmonary, and neurobehavioral influence of tobacco smoke.

This is surely in keeping with the mission of the Institute; at the same time

it is well that consideration is being given to product modification.        The

College  of Agriculture at    the University   of Kentucky   is internationally

recognized for its research in tobacco production, and faculty from that

college should have strong ties with the Institute.

                                       16