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Part of Minutes of the University of Kentucky Board of Trustees

3. U.S. Patent Application Serial Number: (to be assigned) Filed: January 10,2008 Title: "Substituted arylidenamino guanidines for use as selective NMDA receptor inhibitory modulators" Inventors: Drs. Peter Crooks, John Ring, and Sundar Neelakantan (Pharmaceutical Sciences) and John Littleton (Kentucky Tobacco Research and Development Center) Technical Description: The present invention relates to arylidenamino guanidine compounds that modulate the NMDA receptor complex. The invention also relates to methods of treating NMDA-related neurological diseases by administering such compounds. Summary: NMDA antagonists are a category of drugs used in treating pain resulting from damage to the nervous system. Unfortunately, such drugs currently produce undesirable side effects, such as dizziness, headache, and hallucinations. The inventors have designed better NMDA antagonists that produce fewer and milder side effects. Patent Activities Fiscal year to date as of January 31, 2008 Number of Patent Applications Number of Patents Issued Patent Income 6 7 $752,203