Summary: Dr. Webb and Mr. Kroemer have identified a class of proteins whose
increased presence increases longevity of and protein production in cells.
Specifically, they provide methods of increasing the levels of the identified
proteins in cells to take advantage of the increased longevity and protein
5. U.S. Patent Application Serial Number: (to be assigned)
Filed: January 3, 2005
Title: "Bis-Pyridino Containing Compounds for Use in the Treatment of CNS
Inventors: Dr. Peter A. Crooks, Mr. Joshua T. Ayers, Dr. Vladimir Grinevich,
and Dr. Sageetha P. Sumithran.
Technical Description: The present invention provides N-n-Alkylation of
nicotine which converts nicotine from an agonist into an antagonist specifically
for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked
dopamine release. Conformationally restricted analogs exhibit both high affinity
and selectivity at this site, and are able to access the brain due to their ability to
act as substrates for the blood-brain barrier choline transporter.
Summary: Drs. Crooks, Grinevich, and Sumithran and Mr. Ayers have
chemically altered nicotine. This altered form of nicotine can pass into the brain,
blocking the effect of nicotine and natural nicotine-like compounds on a subset of
neurons. These compounds can be used to study diseases such as myasthenia
gravis, Parkinson's disease, Alzheimer's disease, schizophrenia, eating disorders,
and drug addiction.
6. U.S. Patent Application Serial Number: (to be assigned)
Filed: January 12, 2005
Titled: "Method for Protecting Against Neurological Damage Following Acute
Inventor: Dr. William F. Maragos.
Technical Description: The present invention provides a method for protecting
against neuronal damage following an acute neurological insult and comprises
identifying a patient who has been subjected to the acute neurological insult;
providing a mitochondrial uncoupler; and administering a neuroprotective dose of
the mitochondrial uncoupler to the patient during a therapeutic window, which
extends from immediately following the acute neurological insult, wherein a
neuroprotective effect is produced.
Summary: Dr. Maragos has invented a method for treating some forms of brain
injury, such as stroke. The method represents a new use for a drug that is not
currently used therapeutically. That drug belongs to a class of drugs known as
"mitochondrial uncouplers" that promote cell survival.