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Gallery, WT Young Library biochemical processing machinery. This structural perspective
has led to new insights into the molecular basis of cellular . 1/
mechanotransduction  the process by which living cells sense , I" /,
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i AM WELCOME biochemistry It also has led to the creation of human "organ~on .  . ' .
Dr. Eli Capilouto, University of Kentucky President aachip" microdevices that recapitulate the complex structures and . . .
Auditorium, W.T. Young Library functions of living organs, which represent powerful new in vitro  . I. '. \ , ,1 ,
tools for modeling human physiology and disease. EST, l: I M ED Ellllllwlg ,, NTUN NAEF .
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organize matter with nanometer precision To achieve this, ' DM DUSTEH SESSlUN ,. ., , , .. .
scientists have investigated a large variety of materials including Ballroom, ng Alumni House ' vflt - . . W .,
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"bottomup" and "topdown" approaches, Among all of the 2.3% pM DR TODD VEATES " ' _ 'T l g,
' remarkable achievements made, the success of DNA self '. . '. . "1::7

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broad attention. in this talk I will present our efforts in using DNA a g y g D llplE/Alyqumn .'

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r . protein assemblies (such as Virus capSIds) have been studied l], p ,l l {,1} i3

scaffolds Will also be discussed. . . . , L0 LIJ  7:7,:5,7E,~,_,7,.z~
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BREAK REFRESHMENTS referred to as bacterial microcompartments. They serve as "' x to D: 7, - .7 ,, , A N f

primitive metabolic organelles in many bacteria by encapsulating g g o LLI lUlBL llllllllllll \VAE/Alllgy :

sequentially acting enzymes within a selectively permeable .C 4.. L0 U
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Harvard University studies. On the engineering side, sophisticated natural protein 0 _ >- DJ ngllllllllllglllll 1m: iLlllglllll'ylmM
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mechanical forces play in control of cell and tissue development, to form a variety of complex, symmetric architectures. Recent a G) C D: 1,,
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new bioinspired materials and devices. Living cells form and 12 or 24 identical subunits in cubic arrangements. Symmetric (1) C (D D l
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components, yet they exhibit great robustness, mechanical also possible. Natural and engineered protein assemblies will be  . .l
strength and biochemical efficiency. This is possible because discussed, along with their future prospects for synthetic biology a
they use tensegrity' architecture to mechanically stabilize their and biomedical applications, I. J

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