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M Thirt Fourth Annual
2008 PROGRAM - 29.: f3 y - .{v A
8:30 am. Registration 8: Continental Breakfast, Atrium 12:00 pm. Lunch, Conference Room (GP-137), Chemistry 2:32 I   7} } 77} .};-:tf?.rf73 } 3}: V }_
(Room 165), William T. Young Library -Phy5ics BUIldlng 'E m E 70 7}. 7377:: 53.17%? .27323"27'5'..":,;:-77~.r
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9:10 am. Welcome by Dr. Kumble R. Subbaswamy, 1:30 pm. Dr. Harry C. Dorri, Virginia Polytechnic Insti- 5 g _ Xuz. ,-.:,"-.:.;.};} .7 V7-V}7,} emls ry } }.V }V.7}}}}}77e_..7/;}.7}}
Provost, University of Kentucky - Auditorium tute and State Univer5ity } E CL} E 3 E ,, afrrl 737.: } }}7}}}7}}}}7
(Room 1-52), William T. Young Library "Endofullerenes: New NanoProbes for Diag- 09- g 290}? gtggd & 33 715} t7-,7Z:.*:3f?.}
. . . '- 2.3 32.727127: -.,.'-' 7 '77:
9120 am. INtFOdUCtOW Remarks ' Dr. Steven W- Yates, The encapsulation of metals and nonmetals in fullerenes 8  7.737.}. Eiiiiktfil 33%}53
Chairman, Department of Chemistry, Univer- (endofullerenes) is providing new Vistas In medical research. 2 $@%.& Molecular 7;? 3%}
sity of Kentucky Endofullerenes, because of their shapes. capacity for multiple ;\VV}V}}.}V}::}}};4.J f, 7 HE
. . endo encapsulants, isolation from the bio-enVironment}, and 3:3,} _ j}
9:30 am. Dr. Thomas J. Meade, Northwestern }Univers}ity exo functionalizability. are ideal nano-constructs on which to 5.7w&}};237}3.77 Blology llilthlhif'svrl' .77}
.:seeing is Believm'Vg: Biomedical Dlagnostics engineer next generation diagnostic and therapeutic biomedi- 974597} .7 35."??? 225.33
of the 21st Century cal nanoprobes. In our VT CNC laboratory, we have reported :t-ffiiiriggzjl lhjicw
Fundamental biological and clinical questions have a family of very stable metal endohedrtal| gntitatllofullarene: a]? 3773? ghfE}:
, . . . . . EMFS), A3. B N@Ceo (x = 0-3, A B = me a s a are onne :73} V 3.? V 3-..71'51'37 "2. 7}}:
dr'V37 technological advances 'l diagnostilc techniques. Frfhm l/ia a trimetallixc nitride template (TNT) process. To illustrate, 3.5737727: 7577;} .l V :31. 77 .777; 323%
ex wvo DNA chip-analysis. tfo in twvodmo etiu a7r lmggllfnce: recent in vitro and in vivo studies have demonstrated markedly f 73.74773: __ :17, 1}}; :72}?
last decade has seen Slgm man an - con inumg - ' enhanced 1H MRI relaxivity (~2 orders of magnitude) for func- eligdl..__:2~ 2 7: 7v}; , 9 f .7, 33:73}? :7
We are developing new tools t07 Investigate the male? 9f tionalized gadolinium EMFs in comparison with GdDTPA 53:79:2377-77-7': 72G}; 7/ 7} 995:7??? "T?
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.' 7 -  -  : netic resonance imaging (MR con ras agen. n} is}presen- '2.'...'..= 7.7}, .V} V. 374" 2.55:;
ggliulgilliiihhd (porgt::gxtfsegicggethraetagreengsrgpExits: '22: tation,_we will describe the preparation, characterization, and }}.}} 7291:)l . j V 7} Q gift,- $2.372
ideal for rapid. point-ofcare diagnosis. In vivo molecular im- EOten'atngdgjtl} :zglhlbaillglbseg these new TNT EMF diagnos- 7}; JV }..} .li , 2."
aging has profoundly changed our understanding of biological '6 an p ' $12132 3.} established in the memory of :33 21.7373. } .2;
events. Magnetic resonance imaging (MRI), a_ powerful ex- 2:40 pm. Break (Refreshments Available) 9739297}; 7973;913:757
erimental and clinical tool, offers a non-invaswe means to h-'p 77:5 Anna S. Naff ;,-:},7,.:153t.3~"-.
p ' 2 2 2 2 ' .~ 57'. ca, :_.....\~a.
map StFUCtUFe and fUhCOh by sampling the amount, ow or 3:00 pm. Dr. Wenbin Lin, UniverSIty of North Carolina at 4.73.1775 zthlffs
environment of water protons in vivo. Intrinsic contrast can be Chapel Hill . } _ arr/743}, 71 }}g~777.__}}}g}5} .
augmented by the use of paramagnetic contrast agents. MRI "Developing Hybrid Nanomaterials "for 310- 1' 173;}? .}} Inorganic Materials for 37?} E32373 g
is non-invasive and yields a true volume rendering of the sub- medical Imaging and Cancer Therapy #2.} 32""?33 . . . d ii 5hgm
ject with nearly cellular resolution. We directly observe devel- _ 7 _ ll f effective .7} 7}} V VV. :53: Biomedical Imaging an 27.} 723773.37};
mental events in living embryos by labelling individual pre Early diagnosis 0f diseases a 0W5 or more 7 .7. 7 7}}. 1% Th utics 93:. _ 77$
op ' ' t t th test chance of surVival and LO 3.32 rigs, erape 7. 797777.}77.
cursors with a microinjection of a stable, non-tOXIc, membrane treatment, QIVIhQ Pa Ieh75 e grea f h t' 7 7 > L0 mhiis' #7:} 5K V Hwy,
impermeable MRI lineage tracer and tracking the descendants recovery. 3)! harnessmg the power_o synt e '0 inorganic 3: o w; 3773:} _ 353 leg:%5
in an intact embryo. Temporal analysis of high-resolution, chemistry With that of the latest nanosmence and nanotechnol- .2 >6? g? 7.7.7 7:97,} {7%}
three-dimensional MR images enables the reconstruction of ogy, the Lin QFQUP has developed new hybfld nanomaterials E f, 8 377772;}37}; SPEAKERS igg}
the cell divisions and movements responsible for any particu- for multimodaiirnaging. These} nanomaterials prowde 00" (D 3 to V: 2 23%}33 :}2}%%;}1}77:
' ' tire kinshi toxic and sensmve MRI and optical imaging probes for early I C O 7.77}}}79,7A $7,353.31 ,";;2,3"33'2~.:7;?.-
Iar descendant(s). This technique allows the en p _ _ 7 77 O , ,o.:,.:;, .2 .. V}, 7V3..
relationships of a clone to be determined. The full potential of and noninvaswe detection 0f cancer and inammatory aithritis 7._ Q V 73V}? 3.533923% Thomas J_ Meade Tngf}
this technique requires a highly efcient means of delivering inanimal models, WhICh potentially allows for the therapy to be 0 7}_ g rfwix 3: Harry C. Dorn }}}7}:}}},r}}
charged MR contrast agents. We have developed a library of initiated at the most treatable stage. The L1 QFOLIP '5 also E o _ 2 :}72.5%}V71}V37} b' L' f?
molecular MR probes to elucidate signal transduction mecha- extending this powerful synthetic strategy to developing hybrid (D b C Vaah9 Wen In In 323.33%?
nisms of gene expression in whole animals. The modulation nanoparticles containing potent anticancer drugs- sue the? E '5 9 ES lbhg 3: if
of fast water exchange with the paramagnetic centers of lan peutic nanomaterials can be selectively and more efgcien Y E 5 g) lgilfylbl . _ itlfm
thanide chelates is triggered in vivo by enzymatic processing delivered to} tumors than current chemotherafpy, lea mg to Q2 .>< 13,477 91;? Friday, April 4 2008 f,:&grc}
of the contrast agent or the reversible binding of an intracellu- reduced tOXiCIty to normal cells and more e ective cancer 8 5 3 $76??? 5,; .2} ikjkff
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states. .77; EYE): 7;} , $272,732.79" .77} 77,3}.
_ 4:10 pm. Closing Remarks - Dr. John P. Selegue, De- a :fiwlgml, .7}, Department Of Chemistry 337.7} A".
10540 a.m. Break (Refreshments Available) partment of Chemistry, University of Kentucky 0 }%:~} UniverSIty Of Kentucky 27.)}: VV}}}}}E} 7! 7
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