xt75x63b2k7n https://exploreuk.uky.edu/dips/xt75x63b2k7n/data/mets.xml University of Kentucky University of Kentucky Chemistry Department 19880328 A brochure for the Naff Symposium, an event hosted by the University of Kentucky Chemistry Department supported by the Anna S. Naff Endowment Fund. This brochure belongs to the University of Kentucky Chemistry Department Records collection, accession number 2014ua075. archival material  English University of Kentucky Chemistry Department Contact the Special Collections Research Center for information regarding rights and use of this collection. University of Kentucky Chemistry Department Naff Symposium brochures Fourteenth Annual Symposium on Chemistry and Molecular Biology: "Structure and Function of Small RNA Viral Pathogens" text Fourteenth Annual Symposium on Chemistry and Molecular Biology: "Structure and Function of Small RNA Viral Pathogens" 1988 2017 true xt75x63b2k7n section xt75x63b2k7n I“ C U
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1988 PROGRAM 0 a 3
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71 H“ .
t; 72 59h Fourteenth Annual Symposmm on
A.M. RM. 4; (D 0
9:00 Registration and Coffee-Room 137, 12:15 Lunch, Faculty Club o 3 '3‘
Chemistry-Physics Building (See enclosed card) 8 g (3“
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9:30 Welcome by Presrdent David P. Roselle, 1215 Prof. Eckard Wimmer, State Umversnty of u K: g; m r!’ n
University of Kentucky, Room 139, New York at Stony Brook 8 x2 Che ISt a d
Chemistry-Physics Building Genetic Manipulations of Capsid Protein 01 0
Synthesis and the Formation of Neutraliza- U1 MOIecular 3101093]
9:35 Introductory Remarks . . .
tron Epitopes of Pollovuus
9:40 Prof. Roland R. Rueckert, University of
Wisconsin 2:15 Break
Picornavirus Vaccines and Chemotherapy— 2:30 Dr. Mark A. McKinlay, Sterling-Winthrop
Past, Present, and Future Research Institute bl h d ' th f
The picornaviruses include a number of structurally similar Antiviral Activity of Compounds Which ln- eSta 15 e In 8 memory 0
pathogens including poliovirus, human rhinoviruses (common hibit Picornavirus Uncoating Anna S. Naff
cold), hepatitis A virus, and foot and mouth disease virus; hence A series of orally active antiviral agents which suppress picor-
they are historically important targets for vaccine development and navirus replication through an inhibition of the virion uncoating
contiriue to be key models for development 0f vaccines and an} process has been discovered and developed at the Sterling— _—_—_-'—,'
tivira 5, Determination of their gene sequences and mapping 0 Winthro R hl ~ ~ _ '
J p esearc nstitute in Rensselaer, New York. These an .
antigenic sites and drug-resistance mutations within the tiviral agents have been shown to insert themselves in 'a STRUCTURE AND FUNCTION
3-dimensional structure of these viruses has heightened enthusiasm hydrophobic pocket within the virus capsid protein VPl, and to OF
“N degelOPmSEAOf SVEtdheth peptide vaccines, valccinesdfrom induce large conformational changes (up to 5.5 A) in the viriorl . '
recom inant v an esign 0 improve neutra izing ”195v structure. These conformational changes are thought to stabilize
but success still hinges upon mastery of new research frontiers. the virion and prevent uncoating or disassembly and the subse- SMALL RNA VIRAL PATHOGENS
Some problems and opportunities presented by the special hIOlOQV quent release of the infectious RNA. Representatives of this class _______—_
Of these viruses Will be discussed. of antiviral agents have a broad spectrum of in vitro antiviral ac—
10340 Break tivity against the nesrly 200 serotypes of human rhinovirIstes arid
enteroviruses whic cause diseases ranging in severity rom t e S eakers
1050 Prof. Michael 6' Rossmann, Purdue common cold to life threatening paralytic poliomyelitis and p
University neonatal sepsis. In addition to the potent in vitro activity, these
What Doesnthe Molecular Structure 0‘9 agents are orally effective in preventing paralysis and death in mice MICHAEL G . ROSSM ANN
Viruses Te Us About Viral Functions. - ‘ - - -
. . Infected wrth human-enterowruses. A representative of'thisclass MARK A. MCKINLAY
The structures of the protein shell of a number of srmple of antwrral agents, disoxaril (WIN 51711), 15 currently in clinical
icosahedral RNA plant and animal viruses are now known at trials to evaluate its ability to treat picornavirus infections in man. ' ROLAND R- RUECKERT
atomic resolution. In addition, components'of viral capsids such 3:30 Informal Discussion, Room 137' Chemistry- ECKARD WIMMER
as the haemagglutinin and neuraminidase spikes of influenza Virus Ph i B ild'
and the hexon unit of adenovirus are known in similar detail. These ys cs u . mg ‘ . _
structures have provided a wealth of information on viral assembly, We encourage symposrum part1c1pants, especrally students, to
viral disassembly, the antigenic surface on viruses available to take thls opportunity to meet mm the speakers. ,
neutralizing antibodies, the host cell receptor attachment site, fusion
of viral particles with the host cell, processing of polyproteins during Monday’ MarCh 28’ 1988
maturation and the manner in which antiviral agents can interfere Department Of Chemistry
With the function of a Viral capsid. University Of Kentucky
Lexington, Kentucky 40506-0055

 Fourteenth Annual Symposium on
Chemistry and Molecular Biology
established in the memory of Anna S. Naff
Monday, March 28, 1988, 9:00 am.
Chemistry-Physics Building—Room 139
Department of Chemistry, University of Kentucky
STRUCTURE AND FUNCTION OF SMALL RNA VIRAL PATHOGENS
Michael G. Rossmann, Ph.D., University of Mark A. McKinlay, Ph.D., Rensselaer
Glasgow (Chemical Crystallography). Hanley ° - Polytechnic Institute (Biology). Director of the
Distinguished Professor of Biological Sciences, Department of Microbiology, Sterling-Winthrop
Purdue University. Member of the National Research Institute; Adjunct Professor of Biology,
Academy of Sciences. Topic: What Does the Rensselaer Polytechnic Institute. Topic: Antiviral
Molecular Structure of Viruses Tell Us About Activity of Compounds Which Inhibit Picor—
Viral Function. navirus Uncoating.
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Roland R. Rueckert, Ph.D., University of Eckard Wimmer, Ph.D., University of Got-
Wisconsin (Oncology). WARF Professor of tingen (Chemistry). Professor and Chairman,
Molecular Virology, Institute of Molecular Department of Microbiology, State University of
Virology and Department of Biochemistry, New York at Stony Brook. Topic: Genetic
University of Wisconsin-Madison. Topic: Picor— Manipulations of Capsid Protein Synthesis and
navirus Vaccines and Chemotherapy—Past, the Formation of Neutralization Epitopes of
Present, and Future. Poliovirus.

Parking available free at Commonwealth Stadium on Cooper Drive. Shuttle buses run to the main campus. Additional parking
(for a fee) available in UK Medical Plaza Parking Garage, located approximately one block south of the Chemistry—Physics
Building; this garage can be accessed from both Rose and Limestone Streets—look for Medical Plaza Parking signs. For addi-
tional information, contact Prof. Carolyn P. Brock, Dept. of Chemistry, (606) 257—4741.

Symposium supported by the Anna’S. Naff Endowment Fund.