xt7j9k45td19 https://nyx.uky.edu/dips/xt7j9k45td19/data/mets.xml University of Kentucky University of Kentucky Chemistry Department 19970408 A brochure for the Naff Symposium, an event hosted by the University of Kentucky Chemistry Department supported by the Anna S. Naff Endowment Fund. This brochure belongs to the University of Kentucky Chemistry Department Records collection, accession number 2014ua075. archival material  English University of Kentucky Chemistry Department Contact the Special Collections Research Center for information regarding rights and use of this collection. University of Kentucky Chemistry Department Naff Symposium brochures Twenty-Third Annual Symposium on Chemistry and Molecular Biology: "The Role Combinatorial Chemistry in Drug Design" text Twenty-Third Annual Symposium on Chemistry and Molecular Biology: "The Role Combinatorial Chemistry in Drug Design" 1997 2017 true xt7j9k45td19 section xt7j9k45td19 :2 Twent -Third Annual
1997 PROGRAM y .
____—_—_—_%——___.____- Symposmm on
8:00 a.m. Registration and Coffee - Room 137, 10:40 a.m. Discussion
Chemistry-Physics Building
10:50 a.m. Dr. Kim D. Janda, The Scripps Re- '
8:45 a.m. Welcome by Dr. Fitzgerald Bramwell, search Institute and The Skaggs Chem IS'I'I’Y
Vice President for Research and Institute for Chemical Biology
Graduate Studies, University of Mom Combinatorics to Soluble Polymer &
Kentucky - Room 139, Chemistry- Supported Synthesis
Physics Building MOleCU IC"
' Encoded Combinatorial Chemis '
8:50 a.m. Introductory Remarks - Dr. Art . Recursive Deconvolution try BIOlogy
Cammers-Goodwin. Universrty 0f ° Liquid Phase Combinatorial Synthesis of Peptides
Kentucky ‘ Peptidomimetics, and Small Molecules
. _ ° Multipolymeric Reactions
9:00 a.m. Dr. Arno F. Spatola, Unwersrty of , C o mbi Zy m e s
Lomsvme ’ . ' Combinatorial Polymer Synthesis
Combinatorial Chemistry: The End of
Rational Drug Design? Lessons from _
Macrocyclic Libraries 11:40 a.m. Discussron
i 11:50 a.m. Dr. Hendrik Mario Geysen, Glaxo
. Basic combinatorial Methods Wellcome Pharmaceuticals Inc. . - '
. A Brief Hi§t°riFal Overview Combinatorial Chemistry: A New
' ° A "Realistic" Vlew of the Methods—Not a Panacea Paradigmfor Drug Discovery . a ,
' Why So Much Industrial Attention? _ .
° Parallel Synthesis vs. Mixtures _ _ . ' . . ' eStabI'Shed In the memory 0f
. The Deconvolution Problem ' Personalized Historical View of Combinatorial . Anna 3_ Naf‘f i
’ ' Combinatorial Chemistry at the University of Lou- Chemlstry ' ' ‘
isville ' Combinatorial Chemistry: Perspective of the Phar— v ____—_—_____—
maceutical Industry . .
_ . ° Combinatorial Chemistry at Glaxo Wellcome The ROIG combmatonal
9‘40 a.m. Discusswn ° Combinatorial Approaches to Reaction Screening Chemistry in Drug DeSIgn
_ _ ° Encoding Strategies for Chemical Libraries
9:50 a.m. Dr. :Jonathan A. Ellman, Universrty of . Coupling Chemical Libraries with High Through— —‘—’_“'——
California at Berkeley put Screening of Biological Targets 3
Design, Synthesis, and Evaluation of >. O SPEAKERS
Small Molecule Libraries :3 C.)
12:40 p.m. Discussion .‘0 3 8 Jonathan A Ellman
e g to Hendrik Marlo Geysen
' General Philosophy for the Design of Combinato— 1:00 p.m. Buffet Lunch Facult Club Please 21) E S Kim D. Janda
. ' y D 0
Hal Schemes . return registration form by April 1, LH M >.. Arno F- SpatOIa
' Prudent Selection of Classes of Compounds for 1997 for reservations. Cost $10.00 o “5 M
. . 4—3
Combinatorial Approaches to be paid at registration.) 5 >., ,5
' Heuristic Bioactivity of Known Drugs as Starting 5 a 9 Tuesday, April 8’ 1997
Pomts 1n Combinatorial Approaches 3100 P-m- Discussion with Graduate Students E; 5 at)
' Synthetic Approaches to Maximize Molecular Di— Room 137’ Chemistry-Physics 3 E '5
verSIty Building Q :3 A Department of Chemistry
University of Kentucky
E Lexington, Kentucky 40506-0055

 Twenty-Third Annual Symposuum on
Chem'str & ‘
Molecular B'olog
established In the memory of Anna S. Natl
Tuesday, April 8, 1997 8:00 am.
Room 139, Chemistry-PhySIcs BUIIdIng
Department of Chemistry, UniverSIty of Kentucky
ax. w , .4»: A: f .
.. ’ k ’J
a g ..
2; ii ' . _' >
Arno F. Spatola, Professor of Chemistry and Biochemistry,-Uni- ‘ Jonathan A. Ellman, Professor of Chemistry, University of Cali-
versity of Louisville. Ph.D., University of Michigan; A.B., Cornell fornia at Berkeley. Ph.D., Harvard University; B.S., Massachu-
University;University ofLouisville Trustees Research Recognition setts Institute of Technology; National Science Foundation
Award; Delphi Award (U of L Dental School Research Award); Com— Postdoctoral Fellow, 1989-92.
mission on Academic Excellence.
at? --
Kim D. Janda, Professor of Chemistry, The Scripps Research Hendrik Mario Geysen, Distinguished Research Scientist, Glaxo
Institute and The Skaggs Institute for Chemical Biology. Ph.D., Wellcome Pharmaceuticals Inc. Ph.D., University of Melbourne,
University of Arizona; B.S., University of South Florida; Carl S. Australia; B.S., University of Melbourne. Editor of Molecular Di-
Marvel Fellowship, NIH FIRST Award, Alfred P. Sloan Fellowship. versity Journal and on the editorial board of Peptide Research. Dr.
Founder of CombiChem. Geysen is credited as inventor of combinatorial synthesis.
Free parking available at Commonwealth Stadium in the "K" designated area on Cooper Drive. Shuttle buses run to the main campus. Additional
parking (for a fee) available in UK Medical Plaza Parking Garage, located approximately one block south of the Chemistry-Physics Building; this >
garage can be accessed from both Rose and Limestone Streets - look for Medical Plaza Parking signs. For additional information, call Professor
Arthur Cammers-Goodwin, Department of Chemistry, (606) 257-7076.
1997 Committee: Arthur Cammers-Goodwin (Chair), John E. Anthony, Sylvia Daunert
Symposium supported by the Anna S. Naff Endowment Fund