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2001 PROGRAM in; Twenty-Seventh Annual : 1 $432.;
i Symposwm on 33:32:: :
8:30 am. Registration and Continental Breakfast 11:50 pm. Buffet Lunch, Faculty Club [Please return ; 3,3; 3w12;
Room 137, Chemistry-Physics Building registration card by April 13, 2001 for reserva- 3'" ' ' 3."- 33:1 C h e m isfr ; 9'? 35:.
tions. Cost to be paid in advance or at registra- it; 3 y 2:55.:
9:00 am. Welcome by Dr. Boyd E. Haley, Chairperson, tion: Faculty/Guest ($10.00); Graduate Student {352 33:,
Department of Chemistry, University of ($5.00).) Zige & .45 :9
Kentucky - Room 139, Chemistry-Physics 3&335, 3-,: gig;
Building 2:00 pm. Dr. George D. Rose, The Johns Hopkins ,'B"~g,}fg"~"".i M I I 5.3.T"..._.\;:~:~;-.:5f
University School of Medicine :fifa o ec U a r - 521:1?
9:05 am. Introductory Remarks - Dr. L. Edward DeMoll, How Shall We Unfold Thee? Let Us Count the 4;3 , o 3; . f
Department of Chemistry, University of Ways: Enumerating Conformations in the Wgvjg, B I O I o g y t ;."i;_1j:;;
Kentucky Unfolded State of Globular Proteins lwx .";ij:," .,_-;
MW 4%..
9'10 a.m. gg'hirligitagigrafh Univer5ity Of Washington The Levinthal Paradox has long been a challenge for protein !3,)f3%it WVf);J
The Challenge of Protein Analyses in the Post- folders. According to. this conundrum, an unfolded protein. can 1"<~3J 3- ; 435???
Genome Era" populate an astronomical number of conceivable conformations. Ziiffyig :if~6"3tfi
The length of time needed to sift through this ensemble and find 3333131 ' 373:; $3159:
the native conformation is of order days or years. Yet proteins fold 353. 49/93:,
With the recent availability of genomic data, an understand- reliably in milliseconds. How can they solve this search problem? Zr ;.';?3 (3;. q. .31: ' .
ng of the molecular basis of cellular function depends upon un- Our answer to this question provides useful insight into the un- . {5.13 _.} 3383
erstanding the role of the encoded proteins. Over the years, the folded state of proteins [Pappu, et. al., PNAS, 97, 12565-12570 35:}; FT}; gm 
ate of accumulation of knowledge about protein function has been (2000)]. 031" .5: :7 $3535.15 :
ontrolled by the rate of breakthroughs in key technologies. One {35}? -;.'.."?.,_'." estabshed in the memory of :fikhggtl
uch development during the last decade has been the adapta- l}n"j A S N ff 3? ' .  
ion of Mass Spectrometry to the identication and characteriza 3:10 p-m- Break "jwa nna ' a lg, ; :3"?- I
ion of proteins. The suitability of this methodology for answering _ Z, 4&0? 3%; k4 3.3 .3, 
imely biomedical questions will be discussed. 3:30 pm. Dr. Edward M. Marcotte, University of Texas at 35.2fsgji,",jj. _..__. 5": 
Austin 33," . '3
Bioinformatics: A Pathway to Gene Function" {30" __ 9% Pr OfeOITIICS *g
0:20 3" Break In $31.1, ___________ :.~;iii?:;e.i.:~;3.li=1
to  3. 5 $73?
0:40 am. Dr. Thomas C. TenNilliger, Los Alamos National The sequences 0f more than 80 genomes have shown US 3? 8 551%;33 imqf?'
Laboratory just how few genes have been studied directly. In virtually every m >3 \5 Zglmi'ii SPEAKERS .3333
Structural Genomics: Foundation for the genome, about 1/3 to 1/2 the genes are of entirely unknown func- a % O 33%? 5; fi if
Future of Biology?" tion. while most of the rest of the genes have functions inferred a) 3 8 1,*;~, Edward M, Marcotte $253110
from their Similarity to the small set of experimentally character- 6 5 st- 35 :35} George D. Rose gtkj
. ized genes. However, the genomes themselves contain quite a lot LH M > its-rails??? _ _ 935:5
Th? genome proiects have opened upthe prospect ofacom- of information about the relationships between the genes. New 0 cii M twanls Thomas C- Ten/i/illiger musty;
rehenSIve V'ew and understanding 0f 9' Structural genomics methods analyze the context that genes are found in, such as their *5 O n "1793335; Kenneth A. Wa|sh w.
an prowde a foundation for 3 "0th the determination and patterns of inheritance, fusion, and order on the genome. Analy- 9 a? 8 3.": '3 a}?
naly5is Of protein structure on a genomic scale. RartICIpants 'n sis of this gene context allows assignment of function to many of E 2 155 Z1  M73 4,165.12;
he Consortium for .Structural Genomics have carried out a pilot the uncharacterized genes (for example, assignment of prelimi- g 0; .E 33:23:: I: 'd _| 20 2001 *(q
tructural genomics pr01ect based on proteins from. the naryfunction to more than halfthe uncharacterized genes ofyeast). % 'a N ljkfdiz II CY, Ap" ' 4.31;:
yperthermophile Pyrobaculum aerophilum, and are beginning a Q :3 :3 54 Kile: 55:3
arger project to determine and analyze structures of functionally 133?;1353 33;; 1S-
mportant proteins from Mycobacterium tuberculosis. The les- 4:40 pm. meet withpjakers, Room 137, Chemistry- i:%rj Department Of Chemistry 5&1???
ons learned in this pilot project and the prospects for the field of - ysics ui ing ' i ,3; . was: . . 3
tructural genomics will be discussed.  3g> U-niverSIty Of KentUCky :gg:;3:;'
(http://www.chem.uky.edu/seminars/nafflwelcome.html) Zniii'gg Lexmgton, KY 40506-0055 1' gag}?
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