xt7ttd9n629j https://exploreuk.uky.edu/dips/xt7ttd9n629j/data/mets.xml University of Kentucky University of Kentucky Chemistry Department 20090424 A brochure for the Naff Symposium, an event hosted by the University of Kentucky Chemistry Department supported by the Anna S. Naff Endowment Fund. This brochure belongs to the University of Kentucky Chemistry Department Records collection, accession number 2014ua075. archival material  English University of Kentucky Chemistry Department Contact the Special Collections Research Center for information regarding rights and use of this collection. University of Kentucky Chemistry Department Naff Symposium brochures Thirty-Fifth Annual Symposium on Chemistry and Molecular Biology: "Protein Design and Engineering" text Thirty-Fifth Annual Symposium on Chemistry and Molecular Biology: "Protein Design and Engineering" 2009 2017 true xt7ttd9n629j section xt7ttd9n629j .' ; ' ;\ 1.":- . '2 »' m .0" f .. <1 -~ . ...», ' 4 ,“ . ., m s r“ .. '. 1* 1 .- ,. ,- ' 1",st A“ ,
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2009 PROGRAM 5.,._.,,g Thirty—Fifth Annual ;: 1
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9:10 am. Introductory Remarks - Dr. Steven W. _ 2 _' L; M I I LY
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De Novo Proteins From a Designed Artifi- _ . 3 J .
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Department of Chemistry, Unrversrty of Kentucky ‘ ijgf' j
. presents the » . f

Thirty-Fifth Annual Symposrum on L
» ,_- g gag: I?
, Chemistry &
Molecular B'ology '
Established by M. Benton Naff In memory of Anna S. Naff , r. 7 -
v, Friday, Aprrl 24, 2009 9:00 am. g 2
Room 139, Chemrstry-Physrcs Burldrng Ly; -'
I .i' . 1'35“};
Protein Desrgn and Engineering I ,.
‘ Michael H. Hecht, Professor of Chemistry, Princeton University. Dr. Hecht was born and grew up f ff: f, .
_ g in midtown Manhattan. He received his BA. in Chemistry from Cornell University, where he did under- _' '-; I"
; mtg graduate research on protein folding with Professor Harold Scheraga. He completed his PhD. in Bioi- g
@146: ogy at MIT, where he received the ﬁrst Ph.D. from Professor Bob Sauer’s lab, and did research on ~ g' ‘ ‘ ’
I}; i‘wtx' protein stability and protein/DNA interactions. He did post-doctoral research on protein design in the - l: e;
- ‘ :5; ’g’ labs of Professors David and Jane Richardson in the Biochemistry Department at Duke University g: gm;
- ' 3 Medical School. In 1990, Hecht joined the faculty of the Chemistry Department at Princeton, where he g
i" also holds an afﬁliated appointment In the Department of Molecular Biology. At Princeton Hecht has 3 _ _,
, served as the Director of Undergraduate Studies and Associate Chair of the Chemistry Department. f
Hecht’s honors and awards include a Whitaker Foundation Young Investigator Award, a Beckman , ‘ g
’ Young Investigator Award, and the Protein Society Kaiser Award. He serves on the Editorial Advisory L‘ " 3?
‘ Board of Protein Science, Protein Engineering Design & Selection (PEDS), and Biopolymers. Research in the Hecht T11 ‘ .
laboratory focuses in two areas: the ﬁrst deals with the design of novel proteins and artiﬁcial proteomes and the second _ . , fife?
j is concerned with protein misfolding, the molecular determinants of Alzheimer’s disease, and the search for anti- ‘ .. g
‘ Alzheimer’stherapeutics. g f
L I: Alanna Schepartz, Milton Harris '29 PhD. Professor of Chemistry, Professor of Molecular, Cellu- (“g I
:1 Lg lar and Developmental Biology, Yale University. Dr. Alanna Schepartz was born in Forest Hills, "
'3 ,4 New York on January 9, 1962. From 1978-1982 she attended the State University of New York at Al— ‘ ‘ ‘ g
j: , ~.« 3%... bany where she majored in Chemistry and carried out undergraduate research on organic electro- ‘ g'
*‘t if; ,3; jg chemistry with Shelton Bank. In 1982 Alanna moved to New York City to attend graduate school at . g »
“ YE?“ Columbia University. Here she joined Ronald Breslow's laboratory and received her doctorate in 1987 -. .- ,5;
;. »~‘ ; for research on the mechanism of catalysis by the enzyme carboxypeptidase A. Alanna then traveled . _ “-gf
‘ , , to Peter Dervan's laboratory at the California Institute of Technology where she developed chemical ‘ ,
. ‘ methods to explore the topology of eukaryotic ribosomes and the interactions of ribosomal RNAs with . ‘ » Z ~. ‘.
' ‘ antibiotics. In 1988 she joined the Chemistry Department at Yale University where she is now the Mil- g _;
ton Harris ‘29 PhD. Professor of Chemistry and Professor of Molecular, Cellular, and Developmental ; '
Biology. Research in the Schepartz group focuses on the chemical biology of protein-protein and protein-DNA interac- .., j _g
tions inside the cell, defining the structural and energetic factors that distinguish speciﬁc macromolecular interfaces and g f, “15;:
how the assembly and disassembly of these complexes deﬁne biology. Alanna Schepartz has received a Presidential ' _ “xii—53:11
‘ Young investigator Award (1990), a Morse Faculty Fellowship (1990), a David and Lucile Packard Fellowship Award ; Q“
f (1991), an Eli Lilly Fellowship (1991), a Camille and Henry Dreyfus Teacher-Scholar Award (1993), an Alfred P. Sloan ‘j‘ 3' " v~
; Research Fellowship (1994), an Arthur C. Cope Scholar Award (1995), the A.C.S. Lilly Award in Biological Chemistry i; g "
: (1997), the Dylan Hixon '88 Award for Teaching Excellence in the Natural Sciences (1999), the Iota Sigma Pi Agnes Fay ;‘ - g.
-, Morgan Research Award (2002), and has been named a Professor of the Howard Hughes Medical Institute (2003). In . ~
‘ addition, she has been a member (1995-1998) and Chair (1998—2000) of the NIH. Study Section on Bioorganic and '3', ,
Natural Products Chemistry and serves on the advisory boards of several journals including the Journal of the American - {Zia ‘
Chemical Society, Chemistry & Biology, and Current Opinion in Chemical Biology. 3 _ " 71:; ‘4
:3 iift Igag '2' '7 1‘ Peter G. Schultz, Scripps Professor of Chemistry, The Scripps Research Institute. Dr. Schultz l w
. i ' ‘ ‘ I; C rig did his undergraduate and graduate work at the California Institute of Technology. His thesis work with -g - ._
{g i; i. Peter Dervan resulted in the first synthetic molecules (polypyrroleamides) that sequence—selectively 1,; .j. ,' g A
j? "j ",W cleave DNA. In 1985, after postdoctoral studies at the Massachusetts Institute of Technology with 2'? “5‘ ' . L
L » EC“ .. Chris Walsh, he joined the faculty of the University of California at Berkeley, where he was Professor of g‘ , g;
i L, 7- Chemistry, Principal Investigator at Lawrence Berkeley National Laboratory and an Investigator of the . (E;
, A? g , Howard Hughes Medical Institute. Schultz joined the faculty of Scripps in 1999 where he is currently " ' ' j,..-"-;
'. the Scripps Professor of Chemistry. He is also the Institute Director of the Genomics Institute of the ‘ j. ’9 g'
__ Novartis Research Foundation (GNF) in San Diego, CA. The 500+ staff at GNF are developing and I ’ ' ‘
. ' applying state of the art high throughput chemical, proteomics and genomics technologies to identify ,
‘ novel genes and biological processes, as well as develop new therapeutics for human disease. In I f 'g
1 addition, Schultz is a founder of Afiymax Research Institute, Syrrx, Kalypsys, Phenomix, Symyx Therapeutics, Ilypsa, Ia, '
1 Ambrx and Wildcat Technologies, pioneers in the application of diversity based approaches to problems in chemistry, 5.: ‘ 5
, materials science and medicine. His awards include the Waterman Award of the National Science Foundation, member- ..g_ ' ,_ '
ship in the National Academy of Sciences and National Institute of Medicine, the 1994 Wolf Prize in Chemistry, the 2003 f g _
Paul Ehrlich Prize, and the 2005 Arthur C. Cope Award of the American Chemical Society. ”us -
FREE PARKING is available. For information contact Melissa Wirt at (859) 257-7080 or mgwirt2@email.uky.edu. For .ﬂgg
, additional symposium information, contact Professor Yinan Wei, Department of Chemistry, (859) 257—7085 or 3 f“
. yinan.wei@uky.edu. 55*.- 3; .-",‘;;;:it
2009 Committee: Yinan Wei (Chair), Sylvia Daunert, Anne-Frances Miller, David W. Rodgers (Biochemistry) g“; ,
Symposium supported by the Anna S. Naff Endowment Fund _ “3i
2’ I g?“ {5L .