xt7wst7ds10h https://exploreuk.uky.edu/dips/xt7wst7ds10h/data/mets.xml Bartlett, Elisha, 1804-1855. 1842 books b92-182-30418010 English Lea and Blanchard, : Philadelphia : Contact the Special Collections Research Center for information regarding rights and use of this collection. Typhoid fever. Typhus fever. Malaria. Yellow fever. History, diagnosis, and treatment of typhoid and of typhus fever : with an essay on the diagnosis of bilious remittent and of yellow fever / Elisha Bartlett. text History, diagnosis, and treatment of typhoid and of typhus fever : with an essay on the diagnosis of bilious remittent and of yellow fever / Elisha Bartlett. 1842 2002 true xt7wst7ds10h section xt7wst7ds10h THE HISTORY, DIAGNOSIS, AND TREATMENT OF TYPHOID AND OF TYPHUS FEVER; WITH AN ESSAY ON THE DIAGNOSIS OF BILIOUS REMITTENT A-ND OF YLLLOW FE VER. All deieaen, then, o-ght to bc r,-docel to cert-nI nnl determinate loitl, with the e -m eit-ctnea u we t it da- by botanieitiso, tttlirIr ta t Opluat. hFoc th-erex ae dlintos- th at -ome nader the same be, e ihtI, --hw.lla-,andlig, binto f aitffeit o1 vttare, r qaelle :A tiltr' t tta t.....lIwe ioog, tihetatar, a hisntry t dlii t-co, every .ilolonoph-ct Ityputheuta, oollcl .lttit pei paocohb'l to t r inl itosnour, tight to he titt.ily o-Il -oe, and tha. the t .i.ithbenoted tttl tlei itn-ont acc"racy, miIt. tin thins the gretI exocln ol paititern, h.lo in their pictures copy the soinilent spots or (t1 h.s 1tt the t-igitiolt. "-Sydeetlsom. BY ELISHA BARTLETT, M. D., PaOFESSOR oF THE THEORY AND PRACTICE OF MEDICINE IN TRtANSYLVANIA UNIVERSITY. PHILADELPHIA: LEA AND BLANCHARD. 1842. Entered according to Act of Congress, in the year 1842, by ELI-II A BARTLETT, iIn the Clerk's Otflic of the Distii t Court ci the Dissrict o Massachusetts. BOSTON: FREEM1AN AND BROLLES, PRINTERS, WA.1SHINOTON 5ThEE'r. LATE rROFE TO JAMES JACKSON, M. D. OF BOSTON, SSOR OF THE THEORY AND PRACTICE OF I HARVARD UNIVERSITY, A-D TO W. W. GERHARD, M. D. OF PHILADELPHIA, MEDICINE IN LECTURER ON CLINICAL MEDICINE IN THE UNIVERSITY OF PENNSYLVANIA, This history of two diseases, many points of which, they, especially, amongst his own countrymen, have diligently and successfully studied and illustrated, THIS VOLUME IS RESPECTFULLY INSCRIBED, BY THEIR PERSONAL FRIEND, THE AUTHOR. SEPTEMBER 1st, IS-12. This page in the original text is blank. PREFACE. I HAVE written this book, because I thought, that I saw a want in medical literature, which it might supply. Our science, so far as the great subject of idiopathic fevers is concerned, is passing through a transition period; and many authorities, that were received as standard and classical, only a few years ago, are fast becoming obsolete; at least for American readers. This is particularly true of the leading English treatises on Fever. Neither the works of Fordyce, Armstrong, Southwood Smith, nor Tweedie; nor the elaborate articles on Fever, in the Medical Cyclopedias, Libraries and Dictionaries, can henceforth be regarded as sufficient, or even safe, guides for American practitioners; and the remark is applicable to them, not because they are not works of great excel- lence and value; but for other reasons, whichi will be abundantly obvious in the course of the following pages. Vi PREFACE. I may simply say, here, that their authors describe, prin- cipally, a fever, or form of fever, wvhich is rarely met with in this country; and that they do not represent the actual state of our knowledge upon this subject. It must be regarded as especially unfortunate, that, until within a few years, the greater part of our information, relating to continued fever, has been derived from writers, who have treated, mostly, and under the same name as that gene- rally used by ourselves, of a disease, or form of disease, differing, in many important respects, from that which is most common with us; and, that, in this way, so great a degree of confusion has been introduced into our notions of fever. If the radical defect in our literature of continued fever, thus indicated, had not existed; and if the histo- ries of the disease, which have been given to us by Louis, Chomel and Andral, amongst the French; and by Nathan Smith, Dr. James Jackson, Dr. Hale, and some others, amongst ourselves, were generally accessible, and gene- rally read, there would have been no want such as I have alluded to; and, certainly, I should not have added an- other to the long catalogue of books on fever. A trans- lation, by Dr. Bowditch, of Louis's Researches, was pub- lished a few years ago under the auspices of the Massa- chusetts Medical Society, and has since been in the hands of most of its Fellows. But it is very far from being so generally and thoroughly known as it deserves to be. I may add, that the character of this remarkable work is PREFACE. Vii hardly adapted to the actual wants and tastes of the great majority of our practical men. I may say this, I think, without any risk of giving offence ; for no man's admiration of this work can be more unqualified and pro- found than my own. Constituting, as it does, one of the few imperishable monuments, that have, from time to time, and at distant intervals, been raised up along the pathway of our science; it is, nevertheless, true, that in the present state of the profession in this country; amidst the daily cares and duties of its active members, there are but few, who will devote to this object the time and the labor which are necessary, thoroughly to comprehend its principles, and to master its accurate and minute details. Chomel's Clinical Lectures, so far as I know, have not been published here; Nathan Smith's Essay, excellent as it is, is still very incomplete; and the Reports of Dr. Jackson and Dr. Hale, besides not professing to treat systematically of the disease, are not generally accessible. These, in brief, are the reasons, which have prompted me to undertake the preparation of this treatise. I thought, that the wants of medical science, here at least, demanded a history and comparison of the two chief forms of continued fever, as they are now ascertained to exist, fuller and more discriminating than had yet been written; and these wants I have endeavored to supply. My book aims at no other excellence, and no higher merit, than that of being a methodical and com- Viii PRFFACE. pendious summary of the actual state of our knowledge upon two most common and most important diseases. If it has reached this excellence, and if it possesses this merit, I am satisfied. I have only to add, in conclusion, that one of my lead- ing purposes has been to bring out more clearly and strongly than has hitherto been done, our means of diag- nosis between the different species or forms of fever; and to ascertain and establish their nosological relations. It cannot be necessary to go into any formal vindication of the importance of this diagnosis. Setting it aside, alto- gether, as a matter of science ; it is the first, essential condition of all sound practice. In the following history it will be noticed, that I have spoken of no individual fever, excepting the four, which are more or less fully described; to wit, Typhoid Fever; Typhus Fever; Peri- odical Fever, in its three forms, of Intermittent, Bilious Remittent, and Congestive; and Yellow Fever. The simple reason of this is, that I do not know anything of any other distinct fever amongst us. There may be such a disease as the Simple Fever of Fordyce, or the Ep,'emera of many writers. I know, that adults, some- times, in consequence of great, or protracted, fatigue; and, that children, still oftener, from inappreciable causes, are attacked with headache, loss of appetite, debility, and general febrile excitement, not referable to any local origin; which symptoms, after rest of from one to two or three days, either with or without medicine, usually PREFACE. iX subside, leaving the individual in good health. But whether this kind of disorder should be looked upon as a distinct, established form of fever, seems to me, to say the least of it, very doubtful. As to an Inflanmma- tory Fever distinct from Typhus or Typhoid Fever, I can only say, with Nathan Smith, and Chomel, that I have no knowledge of any such disease. SEPTEMBER Ist, IS42. This page in the original text is blank. CONTENTS. PART' I. TYPHOID FEVER. CHAPTER I. PRELIMINARY MATTERS. ART. I.-Introductory ART. II. - Names of the Disease ART. III. - Methods of Description CHAPTER II. SYMPTOMS. ART. I. - Mode of Access ART. II. - Febrile Symptoms Sec. 1. -Chills . Sec. 2- Heat and State of the Skin Sec. 3. - Pulse ART. III. - Thoracic Symptoms Sec. 1. - Respiration . Sec. 2.-Cough Sec. 3. - Physical Signs Page. 3 5 S 10 13 13 14 16 18 18 19 19 CONTENTS. ART. IV. - Cerebro-Spinal, or Nervous Symptoms . 20 See. 1. -Headache . . . . . . 20 See. 2. - Pains in the Back and Limbs . . 22 Sec. 3. - State of the Mlind. . . . . 22 See. 4. - Physiognomy . . . 25 See. 5. -Somnolence . . . . . 26 Sec. 6. - Vigilance . . . . . . 27 Sec. 7. - State of the Senses . . . . 27 Sec. 8.- State of the Muscles . . . . 28 ART. V. - Digestive, and Abdominal Symptoms . 31 See. 1. - Tongue and Mouth . . . . 31 Sec. 2. - Appetite and Thirst . . . . 33 See. 3. - Nausea and Vomiting . . . . 34 See. 4. - State of the Bowels . . . . 35 See. 5. -Abdominal Pains . . . . . 37 See. 6. - Tympanites. . . . . 37 ART. VI. - Miscellaneous Symptoms . . . 39 See. 1.-Emaciation . . . . . . 39 Sec. 2. - State of the Urine . . . . 39 See. 3. - Epistaxis . . . . . . 40 Sec. 4. - Cutaneous Eruptions . . . . 40 See. 5. - Eschars . . . . 44 See. 6. - Sequelw . . . . . . 45 CHAPTER III. ANATOMICAL LESIONS . . . . . . 46 ART. I. -Lesions of the Circulatory Apparatus . 47 See. 1. - heart and Aorta. . . . . 47 See. 2. - State of the Blood . . . . 49 ART. II. -Lesions of the Respiratory Apparatus . 51 See. 1.-Lungs . . . . . . 51 Sec. 2. - Bronchia, Epig lottis, c. . . . 52 ART III. - Lesions of the Brain and its Membranes . 53 ART. IV. -Lesions of the Digestive and Abdominal Organs . . . . . . 55 See. 1. - Pharynx and Esophagus . . . 55 Xii CONTENTS. Sec. 2.- Stomach Sec. 3. -Small Intestines Sec. 4. - Large Intestine Sec. 5.- Lymphatic Glands Sec. 6. - Spleen Sec. 7. - Liver Sec. 8. - Pancreas; Salivary Glands; Urinary Ap- paratus; and Sexual Organs Sec. 9. - General Remarks CHAPTER IV. CAUSES. ART. I. - Age ART. II. - Recency of Residence ART. III. -Contagion ART. IV. - Miscellaneous supposed C Sec. 1 -Locality Sec. 2. - Season Sec. 3.-Sex . Sec. 4. - Miscellaneous ause 76 78 79 es . . 85 85 94 95 95 CHAPTER V. VARIETIES AND FORMS 97 CHAPTER VI. DURATION, MARCH AND COMPLICATIONS. ART. I. - Duration ART. II. -March and Complications ART. IIl. - Peritonitis ART. IV. -Relapses CHAPTER VII. . 103 . 105 . 106 . 107 . 108 Xiii 55 58 66 68 68 70 71 71 DIAGNOSIS CONTENTS. CHAPTER VIII. MORTALITY AND PROGNOSIS CHAPTER IX. THEORY OF TYPHOID FEVER CHAPTER X. TREATMENT AlT. I. -Dr. Jackson's Method of Treatment ART. II. -Dr. Nathan Smith's Method ART. III. - Chomel's Method ART. IV. -Louis's Method ART. V. -Bouillaud's Method ART. VI. - De Larroque's Method ART. VII. - Miscellaneous CHAPTER XI. DEFINITION OF TYPHOID FEVER PART II. TYPHUS FEVER. CHAPTER I. PRELIMINARY MATTERS CHAPTER II. SYMPTOMS ART. I. - Mode of Access . 123 . 135 . 146 . 148 . 154 . 158 . 166 . 171 . 172 . 174 . 178 . 183 . 186 xlv CONTENTS. ART. II. -Febrile Symptoms . . . . 187 ART. III. - Thoracic Symptoms . . . . 191 ART. IV. - Cerebro-Spinal Symptoms . . . 192 Sec. 1. - Headache; pains in the Back and Limbs 193 Sec. 2. - State of the Mind. . . . . 194 Sec. 3. - Physiognomy . . . . . 197 Sec. 4. - State of the Senses. . . . 198 Sec. 5. - State of the Muscles. . . . 199 ART. V. -Digestive and Abdominal Symptoms . 201 ART. VI. - Miscellaneous Symptoms . . . 206 CHAPTER III. ANATOMICAL LE,-IONS . . . . . . 214 ART. I. -Lesions of the Thoracic Organs . . 216 ART. II. -Lesions of the Brain. . . . 218 ART. III. - Lesions of the Abdominal Organs . . 220 CHAPTER IV. 225 CAUSES CHAPTER V. VARIETIES AND FoRMS CHAPTER VI. DUR. TION AND MARCE . CHAPTER VII. MORTALITY AND PROGNOSIS CHAPTER VIII. DIAGNOSIS CHAPTER IX. TIiEoWiY OF Tyrvpuus FEVER . 245 . 247 . 256 . 266 . 311 TV xvi CONTENTS. CHAPTER X. TREATMENT. Sec. 1.-Bleeding Sec. 2. -Purgatives Sec. 3.- Affusions and Ablutions Sec. 4.- Stimulants and Tonics . Sec. 5.- Miscellaneous Remedies CHAPTER XI. DEFINITION OF TYPHus FEVER . 313 . 319 . 319 . 320 . 323 . 328 PART III. BILIOUS REMITTENT AND YELLOW FEVERS. CHAPTER I. BILIOUS REMITTENT FEVER . 335 CHAPTER II. YELLOW. FEVER . 355 PART FIRST. THE HISTORY, DIAGNOSIS, AND TREATMENT OF TYPHOID FEVER. This page in the original text is blank. PART FIRST. TYPHOID FEVER CHAPTER I. PRELIMINARLY MATTERS. ARTICLE I. INTRODUCTORY. IN Writing a hiistory of typhoid and of typhus fever, I begin with that, of typhoid fever, for three reasons. In the first place,. Ily ovn kno.vledge of the disease, derived from peisoinal observation, is much better than it is of typhus fever. My attention was early and strongly called to its investigation by the remarkable work of Louis upon the same disease, as it shows itself in Paris. My professional life, thus far, has been passed in the midst of a popula- tion, especially exposed to some of its predisposing causes, and amongst whom, it has, very constantly, and at times very extensively, prevailed ; so that a personal acquaintance with this fever of fifteen years' continuance has given me sufficient oppor- tunity to become somewhat familiar with its char- TYPHOID FEVER. acter; more so, at any rate, than with the remain- ing diseases, which I propose, in part, at least, to describe. In the second place, there is good reason to think, that typhoid fever is more generally and extensively prevalent, in various parts of the world, than the other distinct forms of essential or idiopathic fever. This is a point which requires further and more ac- curate observation for its settlemnent; but it is pretty certainly true of the temperate latitudes of Europe and America. The actual extent of its prevalence will be more fully spoken of hereafter. In the third place, typhoid fever has been more minutely, more accurately, more thoroughly studied, than any other distinct formr of essential or idiopathic fever. Although: a coroplex, .and in many respects, an obscure, diseases its diagnosis is,.in. most cases, easily and positively rmade 6ut; Its-natural history has been very fully investigated, and the results of this investigation faithfully recorded and summed up. Its symptoms, its lesions, its causes, so far as these latter are appreciable, have been very exactly ascer- tained and settled ; and they have been very pa- tiently compared with the symptoms, the lesions, and the causes of other diseases. This more com- plete knowledge of the disease renders it a very convenient starting point, and an exceedingly val- uable standard of comparison, in our subsequent study of other forms of fever, more or less related to this, but whose history and character have not been so definitively and precisely established. 4 NAMES OF THE DISEASE. These, very briefly, are the simple and obvious considerations, which induce me to commence this history with a description of typhoid fever. ARTICLE II. NAMES OF TIHE D)ISEASE. I have adopted the term typhoid fever as the name of this disease, simply because it is not par- ticularly objectionable, and because it seems to be coming ilto general use. It is that which is most commonly given to the (lisease by the French, although mniny of their writers have coined other, and as they think, more appropriate appellations. Petit and Serres described it in 1813, under the name of entero-mesenteric fever. This term, as has been observed by Andral, has the advantage of marking the peculiar lesion of the disease, while it is free from the objection of pre-judgi-g, by any im- plication, its nature or character. Bretonnjeau calls it a dotIlincitcrite, from the l)iSttilar inflani-nmation of the it.'testine. Cruveillhier and others have al)- plied to it the name of follicular enteritis. By the Germans it is commonly called abdominal typlihus. In New England it has generally been known un- der the name of typhus or ty3phlous fever ; and by the great majority of l)ractitionles it still continues to be so designated. Since, however, it hias been ascertained, that the disease dillers, in many impor- tant respects, from the typhus of British writers, it has become manifestly necessary to ap)ply to it somc 5 6r YPHOID FEVER, other appellation, and in conformity to the example of Louis, Gerhard, Jackson, and others, I have chosen that of tvyphloi(l lever. It may l)e wenl to say a word here in re-ard to the identity of the continued fever of New En-land with the typlhoid fever of the French pathologists. This identity is very clearly and p)0sitively settled. No one familiar with the disease, as it showvs itself in Paris, and as it is described bV Louis, Chmomel, and Andral, and who reads Nathan Smith's descrip- tion of the Typhous Ferer of New England, can doubt for a moment, so far as the symtoinatology is concerned, that such is the case. Time identity of the p)athological lesions in the fever of the two countries has been more recently established. Dr. E. Hale, Jr., of Boston, published in the Medical Magazine for December, 18.33, an account of three dissections of persons, considered by him to have died with this disease. If the diagnosis in these cases could be looked upon as certain and positive, they wvould constitute, so far as I know, the first pul)Iishecl examples of the intestinal lesion of the disease, as it occurs in New England. The diag- nosis, however, in all the instances, must be re- garded as somewhat doubtful, and the alteration of the intestinal follicles does not seem to have been very clearly or strongly marked. The first authen- tic and unequivocal cases on record, that I have I)een able to find, are two, which were published by Dr. Gerhard, in the American Journal of Medi- cal Sciences, for February, 1835. In the Medical 6 NAMES OF THE DISEASE. Magazine for June, 1835, I gave a short account of the entero-mesenteric alterations in five cases of unequivocal typhoid fever, which alterations corres- ponded exactly to those described by Louis. I have upon my note book the anatomical history of two similar cases, which occurred during the months of January and February, 1833, but which were never published. Dr. James Jackson, Jr., then a medical student, observed the intestinal lesion in a clear case of the disease as early as October, 1830, althoug1h the account of the observation was not made public till 1835.1 Dr. Jackson, Jr., after having studied typhoid fever in Paris, aided and guided by the personal instructions of Louis, again saw the disease in Boston, and in two cases, one of which occurred in 1833, and the other in 1834, he found the characteristic lesion of the intestinal fol- licles and mesenteric glands. An account of these observations w,-as published in 1835. Dr. Jackson, Sen., in his Report on Typhoid Fever, communi- cated to the Massachusetts Medical Society in June, 1838, says, that the alteration of Peyer's glands had been noticed at the Massachusets General hospital, previous to 1833, in cases which were carefully examined. Since the periods above re- ferred to, more extensive and accurate observations, by Dr. J. Jackson, Dr. Male, Dr. Bigelow, Dr. Bowditch, Dr. J. B. S. Jackson, Dr. Shattuck, Jr., Dr. Holmes, and others of Boston; and by Dr. I Memoir of Jaines Jackson, Jr., . 222, U sca 7 S TYPHOID FEVER. Gerhard and Dr. Stewardson of Philadelphia, have uniformly sustained the correctness of these early conclusions, and demonstrated the entire identity of the typhoid fever of Paris and of the United States. ARTICLE 111. METHODS OF DESCRIPTION. There are two methods, either of which may be adopted, in the description of a disease. One of these, and that which, with a few exceptions, has been in universal use from the time of Hippocrates to the era of Louis, consists in a general enumera- tion of the more striking and obvious phenomena of the disease, in their various combinations and progress, constituting a kind of portrait or picture. The other, which has been followed by many wri- ters within the last fifteen years, especially amongst the French, consists, not merely in this general enumeration of the phenomena, their combinations and progress; but in a thorough and careful analy- sis of these phenomena; in a special and particular study of each individual element, which goes to make up the disease; and in a strict estimate of the relative value and importance of each and all of these several elements. This analytical process, this " searching operation," is applied in study as well as in description, not only to the symptoms of a disease, but, to a considerable extent, also, to its pathology-, etiology and therapeutics. Amongst the best examples of the first method, the physiog- 8 METHODS OF DESCRIPTION. nomical portraiture of disease, may he mentioned Sydenham's description of measles and St. Vitus's dance, and Dr. Ware's description of delirium tre- mens. The first and one of the most perfect ex- anmples of the latter is to be found in Louis's Re- searches up)on Phthisis, published in 1823. Each of these methods has its advantages and its disadvantat)es, its excellencies and its defects. By the first, a more complete and integral picture of the disease is presented, at once, to the mind, than can be done by the second. WVe are enabled to see, at a single glance, the formn, the outlines, the features, the physiognomy of the disease. But in many very important particulars, this method is inferior to the second. It is merely a picture of disease ; like all other pictures, more or less like the original, strongly or feebly colored, according to the peculiar taste or ability of the individual artist. It is necessarily wanting in the scientific accuracy of which the second is susceptible. It is less complete, less perfect. The disadvantages of the latter consist in the absence of that wholeness and unity of impression whiclh are made by the former. The mind, in order to get at the integral and entire picture, must arrange and combine the scattered materials, which it has studied separately. As one of the leading purposes of the present work is to point out, as far as our actual knowledge will enable us to do so, the characteristic features of each of the two great forms of continued fever; to stablish, as far as possible, a clear and positive 9 TYPHOID FEVER. diagnosis; to ascertain the resemblances and the differences between them ; I shall rely almost ex- clusively upon the last mentioned method. C1HAIPTER 1I. SYMPTOMS. ARTICLE L. MODE OF ACCESS. There is a good deal of difference, in different cases of typhoid fever, so far as the suddenness or violence of the seizure is concerned. There is no other acute disease, perhaps, in which the attack is more frequently slow and gradual than in this. In many cases it is quite impossible for the patient to fix wvith any accuracy upon the day when his fever commenced. Neither, in many of these same cases, is he al)le to tell in what his sickness con- sisted. lie can only say, that, for several days, he has not enjoyed his accustomed degree of health. He may have merely felt a sensation of mental and bodily languor, an indisposition, or an inability to accomplish his usual labor, either of mind or body. He may have had slight and dull pain in the head, or in the back and limbs, with a general feeling of soreness or of fatigue. At the same time lie may have experienced some sensations of chilliness, alter- 10 MODE OF ACCESS. nating with heat. There may have been, also, diminution, or loss of appetite, moderate thirst, with a dry or clammy state of the mouth. The expres- sion of the countenance sometimes becomes listless and dull, the eye loses its animation, and the mind is either indifferent or apprehensive. There may have been moderate diarrhea with some pains in the abdomen. This obscure and indefinite condi- tion of ill health may continue for more than a week, occasionally for two or three weeks even, vith but sliglt changes from day to day. Often- times there is a slow but steady increase in the severity of these morbid sensations, with a like gradual but regular appearance of other and more characteristic symptoms of the disease, these latter comifng out, day by day, one after another, a com- plete and successive development of the peculiar and stronglv marked phenomena of the disease. In other cases, after an indefinite continuance of this obscure precursory period, there is a sudden supervention of the more violent symptoms. Na- than Smith says, ",the disease attacks in such a gradual manner that we hardly know oil what day to fix its commencement." Dr. James Jackson says, " there is more difficulty, perhips, in ascer- taining the commencement in cases of typhoid fe- ver, thati in mnanv other acute diseases." 2 In a certain proportion of cases, however, pre- cisely how large, 1 am not able to say, the access l A Practical Essay on Tvpheus Fever. By Nathan Sinmi, M D. 2 Report on the 'T'yphoid Fever. By James Jackson, M. D. I I TYPHOID FEVER. of the fever is more violent, and its period much more distinctly marked. Chomel, indeed, says, that most frequently the invasion is sudden, coming on in the midst of perfect health, unexpectedly, and not preceded by any precursory symptoms. Of one hundred and twelve cases, in which this point was exactly observed, the access was sudden in seventy-three; in the others there were obscure, premonitory symptoms. The mode of attack, in these cases, is various; most frequently, perhaps, by a chill, accompanied by debility and head-ache, and followed by heat and thirst. In other cases, the mode of attack is different. During a grave epidemic of typhoid fever, which prevailed in the city of Lowell, in the winter of 1834-5, 1 saw two cases, in which the first feelings of ill health, ex- perienced by the patients, so far as could be ascer- tained from them, consisted of severe, griping pains in the bowels, accompanied with tenderness on pressure. In these cases, diarrhea was an early and prominent symptom. In another, and that a fatal case, the patient had been at her usual work during the day, and on getting into bed at night, felt lame, this being the first feeling of sickness of which she was conscious. But, whatever be the mode of attack, whether this be slow, insidious, creep- ing and obscure, marked by no obvious and promi- nent symptoms, or, on the other hand, sudden and violent, -in either case, the disease goes on, for a considerable period of time, varving, of course, ac- cording to its severity and its favorable or fatal ter- 12 FEBRILE SYMPTOMS. mination ; during which progress it is characterized by a greater number and variety of symptoms; in themselves, in their combinations, and their succes- sive appearance, peculiar to this fever, than are to be found in any other form of acute disease. These several symptoms, classified and arranged, I now proceed to describe, as fully and faithfully as the present state of our knowledge will enable me so to do. ARTICLE 11. FEBRILE SY MPTOMS. SEC. I. - Chills. Like most acute diseases, ty- phoid fever is attended by chills or rigors. These are, generally, not very severe. Dr. Jackson says, that in the Massachusetts General Hospital, rigors were much less frequent than chills. Nathan Smith observes, merely, that in the commencement there is, generally, some degree of chilliness felt by the patient. Of thirty-three fatal cases, cited by Louis, thirty-one had chills; in one fourth of which iumber they were severe, accompanied with trem- bling. Of forty-five grave cases, recovered, all were marked by chills, excepting three ; and of thirty-one mild cases, there were chills in twenty- four. This symptom, in a great majority of instances, is present at the commencement, or very early in the disease. It is one of the most constant attend- ants upon the formal access of the fever. The I13 TYPHOID FEVER. chill occurs oftenest in the course of the day, and in a large proportion of cases is repeated, more or less frequently, during the early period of the dis- ease. It is not less constantly present in cases amongst children than it is amongst adults. SEC. II. - Heat and State of the Skin. Follow- ing the chill or rigor, and in the intervals, when these are repeated, there is, almost always, increas- ed heat of the skin. This heat varies very much in different respects. In many patients it is quite moderate in degree, and pretty uniformly diffused over the body. In others the morbid heat is high and burning, and not unfrequently very unequally distributed. Nathan Smith says, " sometimes the head and trunk will be excessively hot, while the extremities are cooler than natural ; at others, the extremities will be preternaturally hot, when the body is but moderately so. One cheek will often appear of a deep red color and be very hot, while the other remains pale and cool ; as its color and beat subside, they seem to cross over and affect the opposite check in the same manner. This color and heat usually extend so far as to include the ear of the affected side." In. the latter state of grave and fatal cases, the intensity of the morbid heat frequently diminishes, and in mild cases it is not often very high, even in their early periods. This morbid heat. as one of the elements of the exace