xt7zcr5ncw95 https://exploreuk.uky.edu/dips/xt7zcr5ncw95/data/mets.xml University of Kentucky University of Kentucky Chemistry Department 19860407 A brochure for the Naff Symposium, an event hosted by the University of Kentucky Chemistry Department supported by the Anna S. Naff Endowment Fund. This brochure belongs to the University of Kentucky Chemistry Department Records collection, accession number 2014ua075. archival material  English University of Kentucky Chemistry Department Contact the Special Collections Research Center for information regarding rights and use of this collection. University of Kentucky Chemistry Department Naff Symposium brochures Twelfth Annual Symposium on Chemistry and Molecular Biology: "Radionuclides in Chemistry and Medicine" text Twelfth Annual Symposium on Chemistry and Molecular Biology: "Radionuclides in Chemistry and Medicine" 1986 2017 true xt7zcr5ncw95 section xt7zcr5ncw95 R? E E
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1986 PROGRAM , ‘9. E. 5
m ‘8 E g Twelfth Annual sympOSlum on
O H-
A.M. distribution of neuroreceptors in a living human brain. The tech- E H“ o
I 10:00 Coffee—Chemistry-Physics, Rm. 137 nique is called positron emission tomography, a powerful imag— - g 8
_ ing technique capable of providing an unprecedented look at 4}- :3
1030 Welcome and Introduction, Rm. 139 chemistry of the living, working brain. Since the first successful a E g Chemistry and
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10:35 Introductory Remarks study, we have developed methods for the study of five different a ‘5‘ a
Dr. Rosalyn S. Yalow neuroreceptor systems—dopamine, serotonin, opiate, ben- . g; 0
10:45 CYCLOTRONS, LABELED zodiazepine, and acetylcholine—and have performed over 300 8 Q MOIeClllal' 8101093]
COMPOUNDS, AND PROBING HUMAN BIO- studies. Among our findings to date are that dopamine receptors a
CHEMISTRY decline almost 50% between the ages of 20 and 70 years in nor-
mal men and to a lesser degree in women, that drugs used to
Dr. Alfred p, wolf treat schizophrenic patients effect a nearly complete blockade of
G or von Heves laid the foundation for the tra t metho dopamine receptors in the caudate nucleus and putamen, that _ .
in 1313??" 1935 he til/as the first to apply it to anin::l studie: vitamin B6 is an important co-factor in the synthesis of dopamine established in the memory Of
curiously enough to a problem in metabolism. The tracer method receptors, and that the total quantity of dopamine receptors is Anna S Naff
has evolved as one of the most powerful techniques in basic reduced in patients with Huntington’s disease while the concen-
chemical and biomedical research. Positron Emission Tomography tration per unit volume of caudate nucleus is normal or even
is a sophisticated application of the tracer method used to probe increased. ——-—
and quantitate human biochemistry. A key issue is the nature of
the tracer used as the probe. Today, tracers for glucose I , .
metabolism, oxygen utilization, neuroreceptor ligands, protein syn- - - RADIONUCLIDES [N
thesis, neoplastic cell turnover, and general pharmacokinetic
studies are being prepared and studied in humans to assess both Coffee Break . t CHEMISTRY AND
normal and pathological states The compounds used are label- ‘ 3:00 RADIOIMMUNOASSAY: 1986 I
ed with positron emitters: mainly carbon, fluorine and oxygen and MEDIC'NE
to a lesser extent nitrogen. They are prepared in place using a D'- Rosalyn 3- Yalow
cyclotron and converted to precursors, i.e., substances which can Radioimmunoassay (RIA) came into being hOt by directed —_—_——
be used in synthesis of higher molecular weight materials. The deSiQh bUt as a fall-out from investigations into another, apparently
presentation will trace the preparation of the radionuclides and unrelated, problem, namely, studies 0‘ the diSh'lbUtiOh and
the labeled compounds placed in the context of the concomitant metabolism of radioactively labeled insulin. We observed that vir~ Speakers
biological methods used to allow determination and quantitation tually all insulin»treated subjects develop ih5Ullh’blhdihQ antibodies.
of a particular physiological or biochemical process in humans. We appreciated that the methods developed for quantifying Ch"
Recent research in synthesis and application of antipsychotic drugs culating antibody to “1511“" COUld be adapted to the measurement ROSALYN S . YALOW
and tumor probes will be highlighted. of insulin itself in plasma and other fluids. The concentratton of HENRY N. WAGNER, JR.
the unknown is determined Simply by comparing its inhibition of
the binding of labeled antigen to antibody with that of known stan- ALFRED 19- WOLF
dards. RlA is a test-tube method now used in thousands of
laboratories throughout the world, even in scientifically less-
P.M. developed countries, to measure the concentrations of hundreds
12:15 Buffet Lunch, Alumni House of substances of biologic interest. It was first used in endocrinologic
(Cost $5.00, Pay at Registration.) Please research and clinical diagnosis. Its applications now cover a much
retum card for msewafion. broader spectrum. Gastro-enterology, neurzendocrinology, plihar- Monday, April 7’ 1986
macology and toxicology, biochemistry, ateriology, viro ogy, _
1:30 NEW IMAGES OF THE BRAIN enzymology—all have felt the impact of RIA. Radioisotopic Department Of ChemIStry
Dr. Henry N. Wagner methodology, as exemplified by RIA, has shown the potential for 2 University of Kentucky
We can now measure how chemicals affect different regions opening new “Stag m biology and medicme. E 3 Lexington, Kentucky 40506—0055
of the living human brain One area involves the study of drugs— 9? (g 'c :3“
in-vivo neuropharmacology; another involves the study of toxic g '3‘ .U tn 5‘
chemical effects—in-vivo neurotoxicology. Two and one half years c? 7* g; g a?
ago we were able to achieve the first quantitative imaging of the Informal 5°C“! hour L" § § 5-
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:. ~33— 8"

 Twelfth Annual Symposium on
Chemistry and Molecular Biology
established in the memory of Anna S. Naff
Monday, April 7, 1986 10:30 a.m.
Chemistry—Physics Building—Rm. 139
Department of Chemistry University of Kentucky
~' " as" ”1“ " «
A . . l :; w. e).
l ROSALYN s. YALOW, PhD. r/i ’ ’ i
I , Physics, 1977 Nobel Laureate, \ " '
., > ' American College of Physicians \ ‘
' Award, American Association of ‘ ' i
, Clinical Chemists Award and -. l
other prestigious awards. Mem-
HENRY N. WAGNER, JR, ber of the National Academy of ALFRED P. WOLF, PhD.
M.D., 1972 Rec1pient of First Sciences, Senior Medical Inves— PhySical Organic Chemistry,
Vikram .Surhabel Gold Medalby ti gat or, VA, Chief of the Ra di 0_ 1971 American Chemical Soci-
the Society of Nuclear Med1c1ne immunoassay Reference Lab- ety Nuclear Applications Award,
of India, 1976 Georg von oratory, VA. Medical Center, 1981 Paul Aebersold Award in
Hevesy Medalist. Professor of Bronx, New York. Topic: “Ra- BaSlC Sc1ence. Chairman De-
Med1c1ne, Radiology. and Envi- dioimmunoassay: 1986” partment of Chemistry Brook-
ronmental Health Sc1ences, Di- haven National Laboratory.
7 rector of the Divisions of Nuclear ,, Topic: “Cyclotrons, Labeled
Medicine and Radiation Health Compounds, and Probing
Sciences, Johns Hopkins Uni- Human Biochemistry”
versity, Baltimore. Topic: “New
Images of the Brain”
Parking available free at Commonwealth Stadium on Cooper Drive. Shuttle buses run to the main campus. Additional parking
(for a fee) available in UK Medical Plaza Parking Garage, located approximately one block south of the Chemistry-Physics
Building; this garage can be accessed from both Rose and Limestone Streets—look for Medical Plaza Parking signs. For addi—
tional information, contact Prof. William D. Ehmann, Dept. of Chemistry, 606-257-4741.
Symposium supported by the Anna S. Naff Endowment Fund.